심상준 교수
학력 : 한국과학기술원 (KAIST),박사
연구분야 : 바이오에너지, 바이오센서
연구실 : 공학관 706호 (TEL) 3290-4853
E-mail : simsj@korea.ac.kr
 
약력
 
- 1988년 서울대학교 화학공학과 학사
- 1990년 한국과학기술원 (KAIST) 화학공학과 석사
- 1994년 한국과학기술원 (KAIST) 화학공학과 박사
- 1994-1996년 : MIT 박사후 연구원
- 1996-2002년 : 한국과학기술연구원 (KIST) 선임연구원
- 2000-2000년 : 세종대학교 겸임교수
- 2002-2011년 : 성균관대학교 교수
- 2011년 - 현재 : 고려대학교 화공생명공학과 교수
 
연구분야
 
- Protein Chip Development and nanobiotechnology
- Metabolic engineering for polyketide synthesis
- Photosynthesis of microalgae for carbon dioxide and hydrogen production
- Biopolymer design and engineering
- Bio-Micro Electro Mechanical Systems(MEMS)
- Biotechnology & Environment
 
주요 논문
 

- Hyun Jin Kim, Eun Jung Lee, Jin-Seung Park, Sang Jun Sim, Jeewon Lee “Reversible and multi-cyclic protein-protein interaction in bacterial cellulosome-mimic system using rod-shaped viral nanostructure”, Journal of Biotechnology, 221, 101-106 (2016)

- Min Eui Hong, Ye Sol Shin, Byung Woo Kim, Sang Jun Sim “Autotrophic hydrogen photoproduction by operation of carbon-concentrating mechanism in Chlamydomonas reinhardtii under sulfur deprivation condition”, Journal of Biotechnology, 221, 55-61 (2016)

- Anh H. Nguyen, Jong Uk Lee, Sang Jun Sim “Nanoplasmonic probes of RNA folding and assembly during pre-mRNA splicing”, Nanoscale, 8, 4599-4607 (2016)

- Jaoon Young Hwan Kim, Ho Seok Kwak, Young Joon Sung, Hong Il Choi, Min Eui Hong, Hyun Seok Lim, Jae-Hyeok Lee, Sang Yup Lee, Sang Jun Sim “Microfluidic high-throughput selection of microalgal strains with superior photosynthetic productivity using competitive phototaxis”, Scientific Reports, 6, 21155, 1-11 (2016)

- Ho Seok Kwak, Jaoon Young Hwan Kim, Sang Cheol Na, Noo Li Jeon, Sang Jun Sim “Multiplex microfluidic system integrating sequential operations of microalgal lipid production”, Analyst, 141, 1218-1225 (2016)

- Young Joon Sung, Jaoon Young Hwan Kim, Ki Wan Bong, Sang Jun Sim “Microdroplet photobioreactor for the photoautotrophic culture of microalgal cells”, Analyst, 141, 989-998 (2016)

- Hyun Jin Kim, Keum-Young Ahn, Kyung Dong Bae, Jiyun Lee, Sang Jun Sim, Jeewon Lee “Adjuvant effect of B domain of staphyloccocal protein A displayed on the surface of hepatitis B virus capsid”. Biotechnology and Bioengineering, 113, 268-274 (2016)

- Min-Eui Hong, Yoon Young Choi, Sang Jun Sim “Effect of red cyst cell inoculation and iron(II) supplementation on autotrophic astaxanthin production by Haematococcus pluvialis under outdoor summer conditions”, Journal of Biotechnology, 218, 25-33 (2016)

- Jong Uk Lee, Anh H. Nguyen, Sang Jun Sim “A nanoplasmonic biosensor for label-free multiplex detection of cancer biomarkers”, Biosensors and Bioelectronics, 74, 341-346 (2015)

- Yoon Young Choi, Min-Eui Hong, Sang Jun Sim “Enhanced astaxanthin extraction efficiency from Haematococcus pluvialis via the cyst germination in outdoor culture systems”, Process Biochemistry, 50, 2275-2280 (2015)

- Jieun Lee, Soomi Ju, In Tae Kim, Sun-Hwa Jung, Sun-Joon Min, Chulki Kim, Sang Jun Sim, Sang Kyung Kim “Evaluation of chemical interactions between small molecules in the gas phase using chemical force microscopy”, Sensors, 15, 30683-30692 (2015)

- Anh H. Nguyen, Jong Uk Lee, Sang Jun Sim “Plasmonic coupling-dependent SERS of gold nanoparticles anchored on methylated DNA and the detection of global DNA methylation using SERS-based platforms”, Journal of Optics, 17, 114022, 1-12 (2015)

- Ho Seok Kwak, Jaoon Young Hwan Kim, Sang Jun Sim “A microscale approach for simple and rapid monitoring of cell growth and lipid accumulation in Neochloris oleoabundans”, Bioprocess and Biosystem Engineering, 39, 2035-2043 (2015)

- Min Kyung Kang, Jeewon Lee, Anh H. Nguyen, Sang Jun Sim “Label-free detection of ApoE4-mediated β-amyloid aggregation on single nanoparticle uncovering Alzheimer's disease”, Biosensors and Bioelectronics, 72, 197-204 (2015)

- Anh H. Nguyen, Jeewon Lee, Hong Il Choi, Ho Seok Kwak, Sang Jun Sim “Fabrication of plasmonic length-based surface enhanced Raman scattering for multiplex detection on microfluidic device”, Biosensors and Bioelectronics, 70, 358-365 (2015)

- Se Young Yoon, Min-Eui Hong, Won Seok Chang, Sang Jun Sim “Enhanced biodiesel production in Neochloris oleoabundans by a semi-continuous process in two stage photobioreactors”, Bioprocess and Biosystems Engineering, 38, 1415-1421 (2015)

- Joo Yeong Lee, Min-Eui Hong, Won Seok Chang, Sang Jun Sim “Enhanced carbon dioxide fixation of Haematococcus pluvialis using sequential operating system in tubular photobioreactors”, Process Biochemistry, 50, 1091-1096 (2015)

- Jong-Hwan Lee, Hyuk Seong Seo, Jung-Hyuk Kwon, Hee-Tae Kim, Koo Chul Kwon, Sang Jun Sim, Young Joo Cha, Jeewon Lee “Multiple diagnosis of viral infectious diseases (AIDS, hepatitis C, and hepatitis A) based on point of care lateral flow assay using engineered proteinticles”, Biosensors and Bioelectronics, 69, 213-225 (2015)

- Min-Eui Hong, Sung Kwan Hwang, Won Seok Chang, Byung Woo Kim, Jeewon Lee, Sang Jun Sim “Enhanced autotrophic astaxanthin production from Haematococcus pluvialis under high temperature via heat stress-driven Haber-Weiss reaction”, Applied Microbiology and Biotechnology, 99, 5203-5215 (2015)

- Anh H. Nguyen, Sang Jun Sim “Nanoplasmonic biosensor: Detection and amplification of dual bio-signatures of circulating tumor DNA”, Biosensors and Bioelectronics, 67, 443-449 (2015)

- Xingyi Ma, Phuoc Long Truong, Nguyen Hung Anh, Sang Jun Sim “Single gold nanoplasmonic sensor for clinical cancer diagnosis based on specific interaction between nucleic acids and protein”, Biosensors and Bioelectronics, 67, 59-65 (2015)

- Anh H. Nguyen, Xingyi Ma, Sang Jun Sim “Gold nanostar based biosensor detects epigenetic alterations on promoter of real cells”, Biosensors and Bioelectronics, 66, 497-503 (2015)

- Hong-Sil Park, Youngsoon Um, Sang Jun Sim, Sang Yup Lee, Han Min Woo “Transcriptomic analysis of Corynebacterium glutamicum in the response to the toxicity of furfural present in lignocellulosic hydrolysates”, Process Biochemistry, 50, 347-356 (2015)

- Ho Seok Kwak, Jaoon Young Hwan Kim, Sang Jun Sim “A microreactor system for cultivation of Haematococcus pluvialis and astaxanthin production”, Journal of Nanoscience and Nanotechnology, 15, 1618-1623 (2015)

- Sun Young Choi, Gyeongtaek Gong, Hong-Sil Park, Youngsoon Um, Sang Jun Sim, Han Min Woo “Extreme furfural tolerance of a soil bacterium Enterobacter cloacae GGT036”, Journal of Biotechnology, 193, 11-13 (2015)

- Sujin Lee, Junghoon Lee, Sang Jun Sim, Misun Cha “Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity”, RSC Advances, 4, 63681-63684 (2014)

- Jong Uk Lee, Ji Hoon Jeong, Doo Sung Lee, Sang Jun Sim “Signal enhancement strategy for a micro-arrayed polydiacetylene (PDA) immunosensor using enzyme-catalyzed precipitation”, Biosensors and Bioelectronics, 61, 314-320 (2014)

- Jong Seob Choi, Sunwoong Bae, Kyung Hoon Kim, Jaoon Y. H. Kim, Sang Jun Sim, Tae Seok Seo “Capture and culturing of single microalgae cells, and retrieval of colonies using a perforated hemispherical microwell structure”, RSC Advances, 4, 61298-61304 (2014)

- Min Sang Lee, Jung Eun Lee, Eunkyoung Byun, Nak Won Kim, Kyuri Lee, Haeshin Lee, Sang Jun Sim, Doo Sung Lee, Ji Hoon Jeong “Target-specific delivery of siRNA by stabilized calcium phosphate nanoparticles using dopa-hyaluronic acid conjugate”, Journal of Controlled Release, 192, 122-130 (2014)

- Joon Chul Park, Seung Phill Choi, Min-Eui Hong, Sang Jun Sim “Enhanced astaxanthin production from microalga, Haematococcus pluvialis by two-stage perfusion culture with stepwise light irradiation”, Bioprocess and Biosystems Engineering, 37, 2039-2047 (2014)

- Hyun Seok Lim, Jaoon Y. H. Kim, Ho Seok Kwak, Sang Jun Sim “Integrated microfluidic platform for multiple processes from microalgal culture to lipid extraction”, Analytical Chemistry, 86, 8585-8592 (2014)

- Ho Joon Jun, Anh H. Nguyen, Yeul Hong Kim, Kyong Hwa Park, Doyoun Kim, Kyeong Kyu Kim, Sang Jun Sim “Distinct Rayleigh scattering from hot spot mutant p53 proteins reveals cancer cells”, Small, 10, 2954-2962 (2014)

- Jungseok Lee, Sang Jun Sim, Michael Bott, Youngsoon Um, Min-Kyu Oh, Han Min Woo “Succinate production from CO2-grown microalgal biomass as carbon source using engineered Corynebacterium glutamicum through consolidated bioprocessing”, Scientific Report, 4, 5819, 1-6 (2014)

- Seul Ki Min, Gwang Heum Yoon, Jung Hyun Joo, Sang Jun Sim, Hwa Sung Shin “Mechanosensitive physiology of Chlamydomonas reinhardtii under direct membrane distortion”, Scientific Report, 4, 4675, 1-9 (2014)

- Phuoc Long Truong, Xingyi Ma, Sang Jun Sim “Resonant Rayleigh light scattering of single Au nanoparticles with different sizes and shapes”, Nanoscale, 6, 2307-2315 (2014)

- Seung Phill Choi, Sang-Hoon Bahn, Sang Jun Sim “Improvement of hydrocarbon recovery by spouting solvent into culture of Botryococcus braunii”, Bioprocess and Biosystems Engineering, 36, 1977-1985 (2013)

- Phuoc Long Truong, Seung Phill Choi, Sang Jun Sim “Amplification of resonant Rayleigh light scattering response using immunogold colloids for detection of lysozyme”, Small, 9, 3485-3492 (2013)

- In-Chun Wang, Min-Jeong Lee, Sang-Jun Sim, Woo-Sik Kim, Nan-Hee Chun, Guang J. Choi “Anti-solvent co-crystallization of carbamazepine and saccharin”, International Journal of Pharmaceutics, 450, 311-322 (2013)

- Jae Jun Yoo, Seung Phill Choi, Jaoon Y. H. Kim, Won Seok Chang, Sang Jun Sim “Development of thin-film photo-bioreactor and its application to outdoor culture of microalgae”, Bioprocess and Biosystems Engineering, 36, 729-736 (2013)

- Sang Ho Won, Jong Uk Lee, Sang Jun Sim “Fluorogenic pH-sensitive polydiacetylene (PDA) liposomes as a drug carrier”, Journal of Nanoscience and Nanotechnology, 13, 3792-3800 (2013)

- Xingyi Ma, Sang Jun Sim “Femtomolar detection of single-mismatches by discriminant analysis of DNA hybridization events using gold nanoparticles”, Analyst, 138, 1794-1802 (2013)

- Min Sun Song, Seung Phill Choi, Jeewon Lee, Young Jik Kwon, Sang Jun Sim “Real-time, sensitive, and specific detection of promoter-polymerase interaction in gene transcription using a nanoplasmonic sensor”, Advanced Materials, 25, 1265-1269 (2013)

- Se Jong Han, Sayeon Cho, Ky Lowehhaupt, So-Young Park, Sang Jun Sim, Yang-Gyun Kim “Recombinant tagging system using ribosomal frameshifting to monitor protein expression”, Biotechnology and Bioengineering, 110, 898-904 (2013)

- Min-Eui Hong, Seung Phill Choi, Youn-Il Park, Young-Kee Kim, Won Seok Chang, Byung Woo Kim, Sang Jun Sim “Astaxanthin production by a highly photosensitive Haematococcus mutant”, Process Biochemistry, 47, 1972-1979 (2012)

- Eun Jung Lee, Keum-Young Ahn, Jong-Hwan Lee, Jin-Seung Park, Jong-Am Song, Sang Jun Sim, Eun Bong Lee, Young Joo Cha, Jeewon Lee “A novel bioassay platform using ferritin-based nanoprobe hydrogel”, Advanced Materials, 24, 4739-4744 (2012)

- Xingyi Ma, Sang Jun Sim “Ultrasensitive detection of a reduced form of nicotinamide adenine dinucleotide based on carbon nanotube field effect transistor”, Analyst, 137, 3328-3334 (2012)

- Phuoc Long Truong, Byung Woo Kim, Sang Jun Sim “Rational aspect ratio and suitable antibody coverage of gold nanorod for ultra-sensitive detection of a cancer biomarker”, Lab on a Chip, 12, 1102-1109 (2012)

- Sang Ho Won, Sang Jun Sim “Signal enhancement of a micro-arrayed polydiacetylene (PDA) biosensor using gold nanoparticles”, Analyst, 137, 1241-1246 (2012)

- Cuong Cao, Xinxing Li, Jeewon Lee, Sang Jun Sim "Homogeneous Growth Gold Nanocrystals for Quantification of PSA Protien Biomarker ", Biosensors and Bioelectronics 24,1292-1297(2009)

- Nguyen,Minh Thu, Seung Phill Choi, Jinwon Lee, Jae Hwa Lee and Sang Jun Sim "Hydrothermal Acid Pretreatment of Chlamydomonas reinhardtii Biomass for Ethanol Production ", Journal of Microbiology and Biotechnology 19(2),161-166(2009)

- Xin Xing Li, Cuong Cao, Se Jong Han, Sang Jun Sim "Detection of pathogen on the catalytic growth of gold nanocrystals ", WATER RESEARCH 43,1425-1431(2009)

- Hyuk Seung Seo, Seong-Eun Kim, Kyung Yeon Han, Jin-Seung Park, Yong-Hwan Kim Sang Jun Sim,Jeewon Lee "Functional fusion mutant of Candida antarctica lipase B (CalB) expressed in Escherichia coli", BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS1794,519-525(2009)

- Je Seob Park, Sung Min Cho, Gui Young Han, Sang Jun Sim,Juhyun Park and Pil J. Yoo "Phase Controllable Transfer Printing of Patterned Polyelectrolyte Multilayers ", Langmuir 25,2575-2581(2009)

- Ji-yeon Roh,Sang Jun Sim,Jongheop Yi, Kwangsik Park, Kyu Hyuck Chung, Dong-young Ryu, and Jinhee Choi "Ecotoxicity of Silver Nanoparticles on the Soil Nematode Caenorhabditis elegans Using Functional Ecotoxicogenomics", Environmental Science&Technology 43(10)3933-3940 (2009)

- Yun Hwa Kim, Jun Pyo Kim, Se Jong Han, Sang Jun Sim "Aptamer biosensor for label-free detection of humal immunoglobulin E based on surface plasmon resonance", Sensors and Actuators B:Chemical 139,471-475(2009)

- Cuong Cao and Sang Jun Sim "Resonant Rayleigh light scattering response of individual Au nanoparticles to antigen antibody interaction", Lab on a Chip 9,1836-1839(2009)

- Jun Pyo Kim, Byung Yang Lee, Joohyung Lee, Seunghun Hong, Sang Jun Sim "Enhancement of sensitivity and specificity by surface modification of carbon nanotubes in diagnosis of prostate cancer based on carbon nanotube field effect transistors", Biosensors and Bioelectronics 24,3372-3378(2009)

- Jae-IL PARK,Jinwon Lee,Sang Jun Sim,and Jae Hwa Lee "Production of Hydrogen from Marine Macro-algae Biomass Using Anaerobic Sewage Sludge Microflora", Biotechnology and Bioprocess Engineering 14,307.315(2009)

- Hyun Soo Jang,Kwang No Park, Jun P. Kim,Sang Jun Sim,Oh J.Kwo,Young Geun Han,Kyung Shik Lee "Sensitive DNA biosensor based on long-period grating formed on the side-polished fiber surface", OPTIC EXPRESS 17(5) 3855-3860(2009)

- Hyun Soo Jang,Kwang No Park,Chang Duk Kang, Jun Pyo Kim,Sang Jun Sim,and Kyung Shik Lee "Optical fiber SPR biosensor with sandwich assay for the detection of prostate specific antigen", Optics Communications 282,2827-2830(2009)

- Cheol Hee Park, Jun Pyo Kim, Sang Wook Lee, Noo Li Jeon, Pil J. Yoo, andSang Jun Sim "A Direct, Multiplex Biosensor Platform for Pathogen Detection Based on Cross-linked Polydiacetylene (PDA)Supramolecules", advanced functional materials 19,3703-3710(2009)

- Hwa Sung Shin, Hyung Joon Kim,Sang Jun Simand Noo Li Jeon "Shear Stress Effect on Transfection of Neurons Cultured in Microfluidic Devices", Journal of Nanoscience and Nonotechnology 9,1-6(2009)

- Chang Duk Kang, Se Jong Han, Seung Phill ChoiSang Jun Sim "Fed-batch culture of astaxanthin-rich Haematococcus pluvialis by exponential nutrient feeding and stepwise light supplementation", Bioprocess And Biosystems Engineering 33,133-139(2010)

- Tam-Anh D. Nguyen , Se Jong Han , Jun Pyo Kim , Mi Sun KimSang Jun Sim "Hydrogen production of the hyperthermophilic eubacterium,Thermotoga neapolitana under N2 sparging condition", Bioresource Technology 101,S38-S41(2010)

- Thao Thi-Hien Pham,Sang Jun Sim "Electrochemical analysis of gold-coated magnetic nanoparticles for detecting immunological interaction", Journal of Nanoparticle research 12,227-235(2010)

- Jeong-Yong Park, Hee Yeop Chae, Chan-Hwa Chung,Sang Jun Sim Juhyun Park, Hong H. Leea and Pil J. Yoo "Controlled wavelength reduction in surface wrinkling of poly(dimethylsiloxane)", Soft Matter6,677-684(2010)

- Seung Phill Choi, Minh Thu Nguyen,Sang Jun Sim,Sang Jun Sim "Enzymatic pretreatment of Chlamydomonas reinhardtii biomass for ethanol production ", Bioresource Technology101,5330-5336(2010)

- Zongrui Zhan, Cuong Cao, Sang Jun Sim "Quantitative detection of DNA by autocatalytic enlargement of hybridized gold nanoprobes ", Biosensors and Bioelectronics 26,511-516(2010)

- Il Kyoung Kwon, Jun Pyo Kim and Sang Jun Sim "Enhancement of sensitivity using hybrid stimulus for the diagnosis of prostate cancer based on polydiacetylene (PDA) supramolecules ", Biosensors and Bioelectronics 26,1548-1553(2010)

- Jun Pyo Kim, Il Kyung Kwon, Sang Jun Sim "The strategy of signal amplification for ultrasensitive detection of hIgE based on aptamer-modified poly(di-acetylene) supramolecules ", Biosensors and Bioelectronics 26,1548-1553(2011)

- Tien Anh Ngo, Mi-Sun Kim, Sang Jun Sim "High-yield biohydrogen production from biodiesel manufacturing waste by Thermotoga neapolitana ", International journal of hydrogen energy 36,5836-5842(2011)

- Jun Pyo Kim, Cheol Hee Park, and Sang Jun Sim "Aptamer Biosensors for Label-Free Colorimetric Detection of Human IgE Based on Polydiacetylene (PDA) Supramolecules ", Journal of Nanoscience and Nanotechnology 11,4269-4274(2011)

- Jun Pyo Kim, Seunghun Hong, and Sang Jun Sim "Apta-Biosensors for Nonlabeled Real Time Detection of Human IgE Based on Carbon Nanotube ", Journal of Nanoscience and Nanotechnology 11,4182-4187(2011)

- Phuoc Long Truong,Cuong Cao, Sungho Park, Moonil Kim and Sang Jun Sim "A new method for non-labeling attomolar detection of diseases based on an individual gold nanorod immunosensor ", Lab on a Chip 11,2591-2597(2011)

- Woo sung Hwang and Sang Jun Sim "A Strategy For the Ultrasensitive Detection of Cancer Biomarkers Based on the LSPR Response of a Single AuNP", Journal of Nanoscience and Nanotechnology, Vol11, 5651-5656(2011)

- Tien anh Ngo,Mi Sun Kim and Sang Jun Sim "Thermophilic hydrogen fermentation using Termotoga neapolitana DSM 4359 by fed-batch culture. ", International journal of hydrogen energy, 36,14014-14023 (2011)

- Seung Phill Choi, Yong-Cheol Park, JungHwa Lee, Sang Jun Sim and Ho-Nam Chang "Effects of L-arginine on refolding of lysine-tagged human insulin-like growth factor 1 expressed in Escherichia coli. ", Bioprocess and Biosystems Engineering, 35, 255-263 (2012)

- Jae Jun Yoo, Seung Phill Choi, Byung Woo Kim, Sang Jun Sim "Optimal design of scalable photo-bioreactor for phototropic culturing of Haematococcus pluvialis . ", Bioprocess and Biosystems Engineering, 35, 309-315 (2012)

- Zongrui Zhan, Xingyi Ma, Cuong Cao, Sang Jun Sim. " Gold-based optical biosensor for single-mismatched DNA detection using salt-induced hybridization", Biosensors and Bioelectronics, 32, 127-132 , (2012)

- Woo sung Hwang , Phuoc Long Truong and Sang Jun Sim "Size-dependent plasmonic responses of single gold nanoparticles for analysis of biorecognition", Analytical Biochemistry, 421, 213-218 (2012)

- Il Kyoung Kwon, Min Sun Song, Sang Ho Won, Seung Phill Choi, Sang Jun Sim* "Signal amplification by magnetic force on polydiacetylene supramolecules for detection of prostate cancer ", 8, 209-213 SMALL (2012)