이지원 교수
학력 : Illinois Institue of Technology, 박사
연구분야 : 생명공학
연구실 : 공학관 711호 (TEL) 3290-3304
E-mail : leejw@korea.ac.kr
 
약력
 
- 1985년 서울대학교 화학공학과 학사
- 1992년 Illinois Institute of Technology 화학공학과 박사
- 1993-1994년 : Institute of Gas Technology, Post-doctoral Fellow
- 1994-1997년 : Hanhyo Institute of Technology, Head of Bioprocess Engineering Lab.
- 1998-2002년 : Korea Research Institute of Bioscience and Biotechnology, Senior Research Scientist
- 2002년 - 현재 : 고려대학교 화공생명공학과 교수
 
연구분야
 
- Protein Nanotechnology
- Nanomedicine
- Recombinant Gene Expression and Protein Engineering
- Microbial Proteomics
 
주요 논문
 

- Hyun Jin Kim, Eun Jung Lee, Jin-Seung Park, Sang Jun Sim, Jeewon Lee* (2016) Reversible and multi-cyclic protein–protein interaction in bacterial cellulosome-mimic system using rod-shaped viral nanostructure. Journal of Biotechnology. 221: 101-106

- Hyun Jin Kim, Keum-Young Ahn, Kyung Dong Bae, Jiyun Lee, Sang Jun Sim, Jeewon Lee* (2016) Adjuvant effect of B domain of staphyloccocal protein A displayed on the surface of hepatitis B virus capsid. Biotechnology and Bioengineering 113(2): 268-274

- Jong-Hwan Lee, Hyuk Seong Seo, Jung-Hyuk Kwon, Hee-Tae Kim, Koo Chul Kwon, Sang Jun Sim, Young Joo Cha, Jeewon Lee*. (2015) Multiplex diagnosis of viral infectious diseases (AIDS, hepatitis C, and hepatitis A) based on point of care lateral flow assay using engineered proteinticles. Biosensors and Bioelectronics. 69: 213-225

- Eun Jung Lee, So Jin Lee, Yoon-Sik Kang, Ju Hee Ryu, Koo Chul Kwon, Eunji Jo, Ji Young Yhee, Ick Chan Kwon, Kwangmeyung Kim* and Jeewon Lee* (2015) Engineered proteinticles for targeted delivery of siRNA to cancer cells. Advanced Functional materials. 25(8): 1279-1286

- Eun Jung Lee, Euna Lee, Hyun Jin Kim, Jong-Hwan Lee, Keum-Young Ahn, Jin-Seung Park and Jeewon Lee* (2014) Self-assembled Proteinticle Nanostructures for 3-dimensional Display of Antibodies. Nanoscale. 6(24): 14919

- Koo Chul Kwon, Ju Hee Ryu, Jong-Hwan Lee, Eun Jung Lee, Ick Chan Kwon, Kwangmeyung Kim, Jeewon Lee* (2014) Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy. Advanced Materials. 26(37): 6436-6441

- Keum-Young Ahn, Ho Kyung Ko, Bo-Ram Lee, Eun Jung Lee, Jong-Hwan Lee, Youngro Byun, Ick Chan Kwon, Kwangmeyung Kim, Jeewon Lee* (2014) Engineered protein nanoparticles for in vivo tumor detection. Biomaterials. 35: 6422-6429

- Jong-Hwan Lee, Hyuk Seong Seo, Jong Am Song, Koo Chul Kwon, Eun Jung Lee, Ho Jin Kim, Eun Bong Lee, Young Joo Cha, Jeewon Lee* (2013) Proteinticle Engineering for Accurate 3D Diagnosis. ACS NANO. 7(12): 10879-10886

- Dae-Sung Lee, Jin-Seung Park, Eun Jung Lee, Hyun Jin Kim and Jeewon Lee* (2013) A Protein nanofiber hydrogel for sensitive immunoassays. Analyst. 137(17): 4786-4794

- Lina Yoo, Keum-Young Ahn, Ji-Young Ahn, Thomas Laurell, Yong Man Lee, Pil J. Yoo, Jeewon Lee* (2013) A simple one-step assay platform based on fluorescence quenching of macroporous silicon. Biosensors and Bioelectronics. 15(41): 477-483

- Jin-Seung Park, Moon Kyu Cho, Eun Jung Lee, Keum-Young Ahn, Kyung Eun Lee, Jae Hun Jung, Yunjung Cho, Sung-Sik Han, Young Keun Kim, Jeewon Lee* (2009) A highly sensitive and selective diagnostic assay based on virus nanoparticles. Nat. Nanotechnol. 4: 259-264.

- Eun Jung Lee, Keum-Young Ahn, Jonghwan Lee, Jin-Seung Park, Jong-AmSong, Sang Jun Sim, Eun Bong Lee, Young Joo Cha, and Jeewon Lee* (2012) A novel bioassay platform using ferritin based nanoprobe hydrogel. Adv. Mater. 24(35): 4739-4744.

- Hyuk Seong Seo, Seong Eun Kim, Jin-Seung Park, Jong Hwan Lee, Ki-Yeon Yang, Heon Lee, Kyung Eun Lee, Sung-Sik Han, and Jeewon Lee* (2010) A Three-dimensional Nanostructured Array of Protein Nanoparticles. Adv. Funct. Mater. 20(23): 4055-4061.

- Jong-Hwan Lee, Jung Suk Kim,20 Jin-Seung Park, Wonbae Lee, Kyung Eun Lee, Sung-Sik Han, Kyu Back Lee, and Jeewon Lee* (2010) A Three-dimensional and Sensitive Bioassay Based on Nanostructured Quartz Combined with Viral Nanoparticles. Adv. Funct. Mater. 20: 2004-2009.

- Lina Yoo, Jin-Seung Park, Koo Chul Kwon, Seong-Eun Kim, Xiong Jin, Hyunggee Kim, and Jeewon Lee* (2012) Fluorescent viral nanoparticles with stable in vitro and in vivo activity. Biomaterials 33(26): 6194-6200.

- Lee SH, Lee H, Park JS, Choi H, Han KY, Seo, HS, Ahn KY, Han SS, Cho Y, Lee KH, Lee J* (2007) A Novel approach to ultrasensitive diagnosis using supramolecular protein nanoparticles. FASEB J. 21(7): 1324-1334.

- Ahn JY, Choi H, Kim YH, Han KY, Park JS, Han SS, Lee J* (2005) Heterologous gene expression using self-assembled supra-molecules with high affinity for HSP70 chaperone. Nucleic Acids Res. 33(12): 3751-3762.

- Seong-Eun Kim, Keum-Young Ahn, Jin-Seung Park, Kyung Rim Kim, Kyung Eun Lee, Sung-Sik Han,and Jeewon Lee* (2011) Fluorescent Ferritin Nanoparticles and Application to Aptamer Sensor. Analytical Chemistry 83(15): 5834-5843.

- Han KY, Park JS, Seo HS, Ahn KY, Lee J* (2008) Multiple Stressor-induced proteome responses of Escherichia coli BL21(DE3) J. Proteome Res. 7: 1891?1903.

- Lina Yoo, Keum-Young Ahn, Ji-Young Ahn, Thomas Laurell, Yong Man Lee, Pil J. Yoo, and Jeewon Lee* (2012) A simple one-step assay platform based on fluorescence quenching of macroporous silicon. Biosens. & Bioelectron. doi: 10.1016/j.bios.2012.09.012. [Epub ahead of print]

- Keum-Young Ahn, Koochul Kwon, Junghwan Huh, Gyu Tae Kim, Eun Bong Lee, Donghyun Park, and Jeewon Lee* (2011) A sensitive diagnostic assay of rheumatoid arthritis using three-dimensional ZnO nanorod structure. Biosensors & Bioelectronics 28: 378-385.

- Keum-Young Ahn, Jin-SeungPark, Kyung-YeonHan, Jong-AmSong, and Jeewon Lee* (2012) YrhB is a highly stable small protein with unique chaperone-like activity in Escherichia coli BL21(DE3). FEBS Letters 586: 1044-1048.

- Hyuk-Seong Seo, Jin-Seung Park, Kyung-Yeon Han, Kyung-Dong Bae, Sang Jeom Ahn, Hyun Ah Kang, Jeewon Lee* (2008) Analysis and characterization of hepatitis B vaccine particles synthesized from Hansenula polymorpha. Vaccine 26: 4138-4144.

- Jong-Am Song, Dae-Sung Lee, Jin-Seung Park, Kyung-Yeon Han, and Jeewon Lee* (2012) The N-domain of Escherichia coli phosphoglycerate kinase is a novel fusion partner to express aggregation-prone heterologous proteins. Biotechnol. & Bioeng. 109(2): 325-335.